In the rule “The Laboratory”, add the following text at the end of the first paragraph:

A Genetic Engineer or an Organism who has a Position of a specific Room is said to be “in” that Room. Otherwise, they are not “in” that Room.

In the rule “Synthesis” replace the text “A Mutation consists of changing the Nucleotide at a specified position in the Genome to a different Nucleotide.” with the following text:

The valid choices for Mutation are listed in the Mutations subrule. Each such Mutation has a Cost, which is the amount of Research Points that must be spent to submit the Mutation request and may be 0, and the Requirements, which must be true for the Genetic Engineer who is submitting the Mutation request and may be None.

In the rule “Synthesis”, add a subrule named “Mutations” with the following text:

{| class="wikitable"
|-
! Mutation !! Cost !! Requirements
|-
| Change the Nucleotide at a specified position in the Genome to a different Nucleotide || 0 || None
|-
| Pick two distinct specified locations in the Genome and swap the two Nucleotides at those positions with each other || 1 || None
|-
| Choose any valid Nucleotide and a specified position in the Genome to insert the chosen Nucleotide || 2 || Must be in the Computer Lab
|}