Remove “Some Codons may be assigned to one or more Rooms, Organisms, and/or Genetic Engineers. There is a publicly tracked table that lists all such assignments.” from the rule “Codons”.

Remove ” and assign that Organism a (not necessarily unique) random Codon” from the table entry for ACT.

Remove “If an Organism’s Stage is at least 3, a dynastic action may not increase that Organism’s Stage unless that Organism’s Codon can be found in the Genome at the time the dynastic action is performed.” from the rule “Evolution”.

Add the Codon “CAT” to the table in the rule Codons, with “Desertfrog” as Discoverer and an Effect of:

If there is at least one Organism in the Wet Lab, randomly choose one of them and move it to the Materials Airlock. Additionally, if there is at least one Organism in the Hallway, randomly choose one of them and move it to the Materials Airlock.

Add a new rule named “Needs” with the following text:

Each Genetic Engineer has a publicly-tracked number named “Needs” which defaults to 0.

In the rule “Synthesis”, in the Synthesize atomic action insert the following steps just before the step “For each Genetic Engineer with a Status of Injured who is in the Medlab, set their Status to Healthy”:

* For each Genetic Engineer who has a Needs greater than 5, set their Status to Injured.
* For each Genetic Engineer, if they are in the Kitchen or Restrooms, set their Needs to 0, otherwise add 1 to their Needs.

In the rule “Mutations”, replace the text “Must be in the Computer Lab” with “Must be in the Computer Room”.

One new Organism synthesized. Two non-conflicting Mutations were processed, one of which overrode an existing ACT Codon. One ACT Codon was processed.

Genome Comparison:
GTACTTCTCCACT
GTACTTCTTCTCT

To the table in “Mutations”, add a Mutation of:-

Remove the Nucleotide at a specific position

With a Cost of 2, and a Requirement of “Must be in the Autoclave”.

Then add a Mutation of:-

The Genome is Refrigerated for the duration of this Synthesis

With a Cost of 0, and a Requirement of “Must be in the Freezer”.

Then in Synthesis, replace “Add a random Nucleotide to the beginning of the Genome” with:-

If the Genome is not Refrigerated, add a random Nucleotide to the beginning of the Genome

In the rule “Codons”, in the Effect for the ACT Codon, after the text “Add a new Organism to a random Containment Cell” add the following text:

and assign that Organism a (not necessarily unique) random Codon

Assign a (not necessarily unique) random Codon to each existing Organism.

In the rule “Organisms”, add a subrule named “Overpopulation” with the following text:

When 5 or more Organisms are in the same Room, that Room is considered Overpopulated.

Survival is an atomic action with the following steps that apply only to the Organisms in a specific Room:
* Select all the Organisms with the lowest Stage in that Room and consider that group of Organisms the Prey.
* Randomly select an Organism from the Prey and remove it from the gamestate.
* Select all the Organisms with the highest Stage in that Room and consider that group of Organisms the Predators.
* Randomly select an Organism from the Predators and increase its Stage by 1 if it is legal to do so.

In the rule “Synthesis”, add the following as the last step in the Synthesize atomic action:

* For each Room that is Overpopulated, perform the Survival atomic action for that Room, repeating the action until that Room is no longer Overpopulated.

Two more Organisms created! There was only one non-conflicting Mutation this time around. Two ACT Codons were processed.

Genome comparison:
TACTTCTGCACT
TACTTCTCCACT

Add a new entry to the table in Codons with a Codon of “AGG”, a Discoverer of “Kevan” and an Effect of:-

For each Room which has multiple Organisms in it, remove all but one of those Organisms at random and add the combined Stages of the removed Organisms to the Stage of the Organism left in that Room.

Remove “, or the fact that they do not want to perform any Mutations” from the rule “Synthesis”.

In the rule “Synthesis” after this text “if two or more Mutations specify the same position, those Mutations are instead not performed” add the following text:

and the Nucleotide at that position must be changed to a randomly-selected Nucleotide (repeat this step for each position that was specified in more than one Mutation)

In the rule “Codons”, add the Codon TGG with JonathanDark as the Discoverer and the Effect as follows:

For each Organism with a Stage of at least 2, randomly select a Room connected to their current Room containing at least 1 Genetic Engineer (excluding all Rooms with the word “Airlock” or “Freezer” in their names), and if there is such a Room, move that Organism to that Room.

On our third synthesis attempt, we have finally created two viable lifeforms! Please treat them well.

Two ACT Codons were processed. Genome before and after the Mutations:

GCTTGTGCACA
ACTTCTGCACT

In the rule “Synthesis”, replace “Genetic Researcher” with “Genetic Engineer”.

Uphold the two Synthesis actions attempted by the Head Researcher at 14:21 on 25 October 2024 and 14:50 on 30 October 2024.

To the second paragraph of Synthesis, add:-

If there are one fewer Submissions than the number of Healthy Genetic Engineers, then the Head Researcher is encouraged to publicly remind the remaining Engineer (on Discord or the blog) that they need to submit a Mutation.

In “Codons”, after “along with their corresponding effect when the Synthesize action is performed” add:-

and optionally the name of a Genetic Engineer (or idle Genetic Engineer) who Discovered them

Add a column called “Discoverer” to the table in “Codons”. Mark ACC as discovered by Desertfrog, CGA as discovered by JonathanDark and ATC as discovered by Kevan.

To the end of the bullet list in “Synthesis”, add:-

* For each Genetic Engineer who Discovered a Codon which is currently present in the Genome, give that Genetic Engineer 1 Research.

In the ACT Codon effect, replace “1 Research Point” with “3 Research Points” and “2 Research Points” with “6 Research Points”.

In “Hypotheses”, replace “may pay 1 Research Point” with “may pay 3 Research Points”.

Multiply every Genetic Engineer’s Research score, and the Cost of every Mutation, by 3.

Second Synthesize action complete. All four Mutations went through, but there were no Codons with effects in the Genome.

For comparison, this was the genome before and after the Mutations (but before the new Nucleotide was added):

ATAGTCGCCC
CTTGTCGACA