Replace the first three paragraphs of “Synthesis” with:-

Each Genetic Engineer has a Planned Mutation, privately tracked by the Head Researcher: this is either a Mutation from the Mutations subrule along with any specified information that it requires, or is blank.

A Genetic Engineer may, as a Virtual Action, pay the cost of a Mutation to change their Planned Mutation to it, so long as they meet any Requirements that Mutation has. If the Mutation requires anything to be specified, they should specify it when taking the action. A Genetic Engineer may also set their Planned Mutation to blank, as a Virtual Action.

Submissions is the number of Genetic Engineers whose Planned Mutation is not blank, out of the total of Healthy Genetic Engineers, and is publicly tracked by the Head Researcher.

If every Healthy Genetic Engineer has a non-blank Planned Mutation, then the Head Researcher can and should perform the Synthesize action, an atomic action consisting of the following steps:

Add a rule called “The Filing Cabinet”:-

The Head Researcher may, at any time, set a Genetic Engineer’s Planned Mutation to match that Genetic Engineer’s most recent Mutation request under the ruleset prior to the enactment of “How to Play the Synthesizer”.

The Head Researcher may repeal this rule at any time.

Remove “Low-Player Mode” from the Building Blocks section of the ruleset.

In the rule “Codons”, replace “Some Codons may be assigned to one or more Rooms, Organisms, and/or Genetic Engineers. There is a publicly tracked table that lists all such assignments.” with the following text:

Codons have either zero Preferences, or one or more publicly-tracked Preferences, each of which may be a Room, an Organism, or a Genetic Engineer. Any Codon that does not have one or more publicly-tracked Preferences is considered to have zero Preferences. The effect of a Preference when applied to that Codon is either defined in other rules, or if not defined, that Preference has no effect.

Rename “Assigned to” to “Preference” in the gamestate.

In “Synthesis”, replace “perform the Synthesize action once every Genetic Researcher has made a new submission” with:-

perform the Synthesize action once every Healthy Genetic Researcher has made a new submission

Add a new Codon to the table in “Codons”, with a Codon of “ATC” and an Effect of:-

For each Room where the total Stages of all Organisms in that Room exceeds the number of Genetic Engineers in that Room, set the Status of all Genetic Engineers in that Room to Injured.

Remove all but the first paragraph from “Injuries”, and move “Injuries” to be a standalone rule rather than a subrule of “Organisms”.

In the rule “Mutations”, add the following text:

When performing a Mutation, the Cost of that Mutation is increased by 1 for that performance if the changes caused by that performance would result in a Codon that has an Effect becoming a Codon with no Effect.

In the rule “Organisms”, add a subrule named “Evolution” with the following text:

Each Organism has a publicly tracked number named “Stage” which defaults to 1.

In the rule “Codons”, add the Codon CGA to the table with the Effect of “Randomly select an Organism, then add 1 to its Stage if it is legal to do so”.

If the proposal “For ease of reference” was enacted, add the following text to the subrule “Evolution”:

If an Organism’s Stage is at least 3, a dynastic action may not increase that Organism’s Stage unless that Organism’s Codon can be found in the Genome at the time the dynastic action is performed.

The “No Cooperation” Building Block is not in effect, so in the spirit of having a more interesting environment of active Codons, I’m seeking out like-minded Genetic Engineers to come to an agreement on editing the Genome. This would be just one time to see how it goes at first. My thinking is that with 4 active Genetic Engineers, if 3 of us divided the Genome up and each worked on a section, the most damage the 4th could do is ruin one of our plans, but not all 3.

Could there be sabotage among the 3 who agreed? Of course. The consequences are low right now, but I would suggest that successful cooperation now could lead to further cooperation opportunities in the future.

I await your thoughts on the matter.

- JonathanDark

Append the following text to the rule “Codons”:

Some Codons may be assigned to one or more Rooms, Organisms, and/or Genetic Engineers. There is a publicly tracked table that lists all such assignments.

Assign a (not necessarily unique) random Codon to each existing Room, Organism, and Genetic Engineer.

First Synthesize action complete. The 5th position was changed from an A to a G; all other submissions either conflicted or did not request a Mutation. None of the Codons had an effect.

In “Codons”, replace “Move each Organism to a random Room connected to its current Position.” with:-

Move each Organism to a random Room connected to its current Position (excluding all Rooms with the word “Airlock” or “Freezer” in their names).

Remove “As a Daily Action, each Genetic Engineer may change their Position to a Room that is Connected to their current Position.” from the rule “The Laboratory”.

Then add to the end of that rule:-

If they have not done so since the last time that the Synthesize action was performed, a Genetic Engineer may change their Position to any Room that they can trace a path of Connected Rooms to from their current Position, so long as:-

• That path does not involve using both doors of the Personnel Airlock
• That path does not involve using the door that connects the Materials Airlock to the Wet Lab (the hatch is too small)

In the rule “The Laboratory”, in “The map of the Laboratory”, add a Room called Medlab positioned south of the Personnel Airlock and Connected via a Door to the Hallway.

In the rule “Organisms” add a subrule named “Injuries” with the following text:

Each Genetic Engineer has a publicly tracked Status which defaults to Healthy and may be one of the following: Healthy, Injured. When a Genetic Engineer’s Status is Injured, they may not take any dynastic actions other than changing their Position to another Room.

Whenever a Genetic Engineer or the Head Researcher performs a dynastic action that moves a Genetic Engineer or an Organism to a Room, and after that dynastic action is performed, that Room now contains at least 1 Genetic Engineer and at least 1 Organism, they must perform the Attack action, which is an atomic action with the following steps:
* Calculate the Threat, which is an integer which may be negative and which is the number of Organisms in that Room minus the number of Genetic Engineers in that Room.
* If the Threat is 0 or negative, skip the remaining steps and consider this action completed.
* Roll DICE5. If the result is less than or equal to the Threat, set the Status of all Genetic Engineers in that Room to Injured.

In the rule “Synthesis”, add the following as the last step in the atomic action Synthesize:

* For each Genetic Engineer with a Status of Injured who is in the Medlab, set their Status to Healthy.

In the rule “Synthesis”, before the text “The Head Researcher can and should perform the Synthesize action”, add the following text:

Submissions is the number of Genetic Engineers who have submitted Mutations since the last time the Synthesize action was performed (or since the beginning of the dynasty if the Synthesize action has never been performed) out of the total of active Genetic Engineers and is publicly tracked by the Head Researcher.

In “Hypotheses”, replace “Each Genetic Engineer has a privately tracked Hypothesis” with:-

Each Genetic Engineer has a Hypothesis which is privately tracked by the Head Researcher